Biology
06102026–2028 syllabus

BIOLOGY · CHAPTER 11

Gas exchange in humans

How ventilation maintains steep gradients at specialised alveoli.

Core + Supplement3 connected sectionsNotes only

LEARNING OBJECTIVES

By the end of this chapter, you should be able to:

  • identify breathing structures
  • explain alveolar adaptation
  • compare inspired and expired air
  • explain ventilation and exercise responses

THE BIG IDEA

How ventilation maintains steep gradients at specialised alveoli.

This chapter builds each process from its structures, inputs and outputs. Follow the connections rather than memorising isolated facts, then use precise biological terms when explaining cause and effect.

01

SECTION 01

Airways and alveoli

Air passes through larynx, trachea, bronchi and bronchioles to alveoli. Cartilage keeps the trachea open; goblet-cell mucus traps particles and cilia move it towards the throat.

DETAILED EXPLANATION

  • Alveoli provide large area, one-cell-thick walls, strong blood supply and ventilation.
  • Oxygen diffuses into capillaries while carbon dioxide diffuses into alveoli.
LABELLED STUDY DIAGRAMAir pathway
1trachea
2bronchus
3bronchiole
4alveolus ⇄ capillary
02

SECTION 02

Ventilation

Thoracic volume changes alter pressure, moving air down a pressure gradient.

DETAILED EXPLANATION

  • Inhale: external intercostals contract, ribs rise, diaphragm flattens, volume rises and pressure falls.
  • Exhale: muscles relax, ribs lower, diaphragm domes, volume falls and pressure rises.
  • Internal intercostals assist forced exhalation.
LABELLED STUDY DIAGRAMPressure mechanism
1volume ↑ → pressure ↓ → air in
2volume ↓ → pressure ↑ → air out
03

SECTION 03

Air composition and activity

Expired air has less oxygen, more carbon dioxide and water vapour, while nitrogen changes little. Limewater tests increased carbon dioxide.

DETAILED EXPLANATION

  • Active muscles produce more carbon dioxide.
  • The brain detects its rise and increases breathing rate and depth.
  • A fair investigation standardises exercise duration and intensity.

QUICK CHAPTER SUMMARY

The ideas to carry forward

  • Alveoli are large, thin, supplied and ventilated.
  • Pressure changes drive breathing.
  • Expired air differs because of respiration.
  • Exercise increases ventilation.